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Vitamin B12 deficiency can cause a methylfolate trap, a condition where folic acid becomes metabolically trapped and functionally impaired, making it difficult to effectively lower Hcy levels even with folic acid supplementation (70)

et al., 2023) and alleviates NAFLD by activating the AMPK/mTOR pathway to induce autophagy and mitigate hepatic steatosis (Tan et al., 2024)

Advancement of lipid-based nanocarriers and combination application with physical penetration technique

Clin Pract 2020;10:1271 29

Sublingual The sublingual, nasal and buccal routes have two advantages they are rapid in onset and, by avoiding the portal tract, have a higher bioavailability