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p.His1153Tyr, has been reported in a patient with Long QT syndrome (PMID: 16414944) and in a sudden death case (PMID: 26164358), and holds uncertain clinical significance (ClinVar Variation ID: 67497), and (ii) FYCO1:c.832_833del

These PTM were indicated as intermediates toward the formation of disulfide bonds, likely affecting signalling pathways 49

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Nrf2-ARE Signaling Provides Neuroprotection in Traumatic Brain Injury via Modulation of the Ubiquitin Proteasome System