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B 12r and B 12s can be prepared from cyanocobalamin by controlled potential reduction, or chemical reduction using sodium borohydride in alkaline solution, zinc in acetic acid, or by the action of thiols

K.R.B is supported by NIH T32GM128596

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There are several forms of VCID, including: Vascular dementia Vascular cognitive impairment Poststroke dementia Multi-infarct dementia Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Subcortical vascular dementia (Binswanger's disease) Cerebral amyloid angiopathy Lewy body dementia (LBD) After Alzheimer's and vascular causes, LBD is the next most common cause of dementia