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Although BSO+L-PAM were not as active in the TX-MM-030h cell line (established at relapse after therapy with myeloablative L-PAM) as in other cell lines, BSO+L-PAM had a greater than additive effect and induced 3 logs of cell kill

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While some meta-analyses suggest that TCM interventions may provide statistically significant benefits compared to conventional therapy or placebo, 24 the effect sizes are often modest, and wide confidence intervals reflect heterogeneity and imprecision