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Generally, the positive effects of treatment begin within 1-2 hours and last for a few days

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importantly, this reporter is not activated when the antioxidant response element is removed (Supplemental Fig

Consistently, miR-145 overexpression in HKCI-C2 cells induced G2-M arrest and apoptosis suggesting that miR-145 has the repressive effect of hepatic malignant growth through negative regulation of IGF-1R

Aguilar MI, Hart R