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Science 313 , 670673 (2006)

This delivery method avoids gastrointestinal breakdown, hepatic first-pass metabolism, and interactions with food or medications that can block uptake

We observed that core ferroptotic processes such as iron overload, mitochondrial dysfunction, lipid peroxidation, and antioxidant failure were conserved between the CNS and ENS, confirming ferroptosis as a broadly conserved mechanism of neuronal injury

& Hellmann, I

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