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Coordinates of the center of mass of the four brain regions which had Treat \(\times\) Group interaction were identified, and the corresponding four regions in AAL were extracted to create the ROI masks [29]

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Still, a strength of this study is the inclusion of any measure of secondhand smoke exposure, which was not available for inclusion in the NHIS study and has not been examined as a potential confounder of the relationship between childhood smoking and COPD risk in prior work

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