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Because they act through non-overlapping mechanisms, some protocols examine them in combination or parallel though combination research should have a clear mechanistic rationale

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Severe allergic reactions including Stevens-Johnson syndrome affect less than 1% of users but can be fatal, typically appearing as widespread skin blistering within 1-3 weeks of starting treatment

This hypothesis is further supported by clinical observations that more than 60% of accumulated fatty acids in the liver are derived from the circulation in NAFLD patients 7,8