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249 Enhanced binding of MeCP2 to GAD1 and GAD2 promoters, which leads to reduced expression of RELN and mRNA, has been found in the cerebellum and frontal cortex in ASD patients

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Dithiol rings are present in both the oxidized state (LA) and the reduced state (DH-LA), endowing both forms with powerful natural antioxidant properties

Therefore, hyperhomocysteinemia-induced depletion of TH may not involve in the development but only in the progression of PD through the degeneration of dopaminergic neurons with secondary deficiency of TH in PD (Kawahata and Fukunaga 2020

In a recent study, Saunderson et al