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SUMOylation regulates the transcriptional activity of NRF2, affects its interaction with other proteins and intracellular localization, and protects NRF2 from ubiquitination-mediated degradation [129]

Activated microglia release IL-1, which stimulates astrocytes to secrete VEGF and proinflammatory chemokines like CXCL2, CCL2, and CCL20, further exacerbating BBB dysfunction [240]

Female mice, aged 6 to 8 weeks, from these backgrounds were used in all experiments

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