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Real-world mechanism validation examples Glaucoma neuroprotection case: 65-year-old with moderate glaucoma, pressure well-controlled at 14mmHg on drops but showing 2-3% yearly visual field loss

The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate

Abbreviations The following abbreviations are used in this manuscript: Supplementary Materials The following supporting information can be downloaded at Figure S1: PRISMA flow diagram illustrating the study selection process

Another possible contributing mechanism is maladaptive neuroplasticity, in which neuronal pathways adapt and conform pathologically to changes in auditory system nerve signaling