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Variations in some of these may contribute directly or indirectly to increase an individuals risk of toxicity and may account for the wide inter-individual variability of paracetamol metabolism reported in some studies [17, 20, 27]

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Funding This work was supported by the Fonds de Recherche Qubec - Sant (FRQS) [Bourse de formation de matrise, 20222023] (F.D.)

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The increased amount of SH groups damage may be critically important to the function of signal-transduction and transcription events that utilize proteins containing these reactive sites (Brandes et al ., 2009)

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