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Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds

[DOI] [PubMed] [Google Scholar] 122.Runnsj A., Liljedahl S., Sagna D., Ekblad M., Alenfall J

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This makes it a potential therapeutic option for conditions such as inflammatory bowel disease (IBD), peptic ulcers, and gastroesophageal reflux disease (GERD), where maintaining gut health is paramount for symptom management and overall well-being

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