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Low Volume of Distribution 5 A drug with a low V d (e.g., less than 15 L) demonstrates a propensity to remain primarily within the vascular compartment (plasma)

SARS-CoV-2 spike glycoprotein binds TLR4 and activates TLR4 signaling increasing cell surface expression of ACE2 facilitating entry (Aboudounya and Heads, 2021)

In contrast, water-soluble iron chelators including DFO cannot accumulate in lipid droplets or persist within parasites long enough to interact with heme/iron as effectively as ARTs

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