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High fat diet exaggerate metabolic and reproductive PCOS features by promoting oxidative stress: an improved EV model in rats

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& Oberley, L.W

These mechanisms exhibit significant synergy: AMPK activation not only inhibits lipogenesis and inflammation but also enhances autophagy and antioxidant responses, while lignans modulate bile acid metabolism via FXR/TGR5 agonism, and polysaccharides preferentially target SREBP-mediated lipogenic programmingunderscoring constituent-specific actions within SCFs bioactive matrix

95% CI (8.01, 11.49) vs 1.22