Many cancer patients struggle with profound fatigue and reduced energy that affects daily functioning
P-glycoprotein is expressed in intestinal mucosa, renal proximal tubules & in capillary endothelial cells comprising the blood-brain-barrier, and in tumor cells (where it functions as a multi-drug resistance mechanism)
In a separate trial, topical GHK-Cu was compared head-to-head with vitamin C cream and retinoic acid for collagen improvement
In preclinical models this dual mechanism produced greater weight loss than a maximal semaglutide dose, and in a Phase 2 diabetes trial higher survodutide doses reduced weight more than semaglutide though human superiority has not been formally established in head-to-head registration trials
Winther KH, Papini E, Attanasio R, Negro R, Hegeds LA (2018) European Thyroid Association Survey on the Use of Selenium Supplementation in Hashimotos Thyroiditis