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One option is a prolonged course of vancomycin therapy with a subsequent gradual tapering (eg, 125 mg 4 times daily for 2 weeks, 125 mg twice daily for 1 week, 125 mg daily for 1 week, 125 mg every other day for 1 week, and 125 mg every 3 days for 2 weeks)

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Long-term treatment with high-dose thiamine in Parkinson disease: an open-label pilot study. The Journal of Alternative and Complementary Medicine 21, no

For individuals with severe, chronic deficiencies, the cumulative benefits build progressively over the first few consecutive weekly sessions

If side effects like stomach upset or flushing are bothersome, the dosing schedule might be adjusted (e.g