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systemic administration carries risks of off-target effects (e.g., promoting tumorigenesis via global ferroptosis inhibition), which have not been addressed in long-term safety assessments

Professor Sikirics research contributions include: Initial isolation and characterization of BPC-157 from human gastric secretions Extensive investigations of gastroprotective and multi-organ tissue healing mechanisms Pioneering studies on musculoskeletal tissue repair including tendon, ligament, and muscle healing Research on cardiovascular protective effects and vascular injury healing Investigations of BPC-157 interactions with nitric oxide pathways and growth factor systems Over 100 published papers examining BPC-157s pleiotropic effects across organ systems His work has established BPC-157 as one of the most comprehensively studied components in peptide-based regenerative research, though human clinical validation remains completely absent

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Kanemura S, Sofia EF, Hirai N et al (2020) Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding

Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions