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Ultimately, it destroys the single most important thing in research: reproducibility

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Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: A systematic review and meta-analysis

[63] have assessed the effect of zinc deficiency and zinc supplementation on antioxidant expression in high-fat diet mice, inducing vascular inflammation and oxidative stress, demonstrating that zinc insufficiency exacerbates antioxidant expression, whereas zinc supplementation improves that expression

Similar results have been observed in porcine oocytes, where the levels of transcriptional activation markers H3K27me3 and H3K4me2 are reduced, while the level of transcriptional inhibition marker H3K9me3 is increased [77]