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Clinical examination revealed a girl with a height of 152.5 cm (10th to 25th percentile), weight of 45.2 kg (25th to 50th percentile), arm span of 158 cm, and occipitofrontal circumference (OFC) of 52 cm (3rd percentile)

It has been suggested that their use over many years could cause physical changes such as shrinkage of the cerebral cortex, as has been shown in chronic alcoholics, and that such changes may be only partially reversible after withdrawal