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Lal A, Porter J, Sweeters N, et al

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The succinylation of p53 inhibits its function and transcriptional activity, which subsequently results in the suppression of p53 target gene expression

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The selective working principle allows FOXO4-DRI to prevent collateral damage to healthy cells that often occurs with cytotoxic chemotherapy approaches to reducing senescent cells

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However, abnormal iron metabolism is associated with several neurological disorders, including hemorrhagic post-stroke epilepsy and post-traumatic epilepsy (PTE)

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Both high-dose paraxanthine and caffeine significantly reduced escape latency compared to control, with high-dose paraxanthine showing approximately 12.1% better performance than caffeine

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