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We thus suggest that a more realistic and standardized method of parasite challenge, preferably using sporozoite stage parasites or natural Babesia -infected tick field challenge, should be also developed and adopted for future trials

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The Nrf2-independent effect of these inducers could result from their ability to activate additional transcription factors that are also able to increase GST expression, such as the pregnane-X-receptor (PXR), which in turn activates ARE signaling (reviewed in [32])