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Fluid retention and edema: During treatment with glucocorticoids and diclofenac, edema and fluid retention have been observed so the formula must be used with caution in patients with a history of decompensation, hypertension or other factors predisposing to fluid retention

Use your judgment: if the vial was stored perfectly, passes visual inspection, and is only slightly past BUD, many researchers make the informed decision to continue using it

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Across the six published trials, the most common adverse events were headache, mild gastrointestinal effects (diarrhea, flatulence, nausea), nasopharyngitis, fatigue, dizziness, and mild injection-site reactions

[DOI] [PubMed] [Google Scholar] 117.Trifonova E.A., Klimenko A.I., Mustafin Z.S., Lashin S.A., Kochetov A.V