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Notably, we show that plasma FGF-21 levels and glucagon secretion are elevated in Taz -KD mice, suggesting a broader metabolic impact of BTHS beyond cardiac dysfunction

Antioxidant defense via Nrf2 pathway activation Oxidative stress, the accumulation of reactive oxygen species that damage cells, mitochondria, and DNA, is a foundational driver of accelerated aging

& Toledano, M.B

Coadministration of trametinib and palbociclib radiosensitizes KRAS-mutant non-small cell lung cancers in vitro and in vivo

Several reports found that vitamin D deficient neonates suffer from a higher risk of developing several disorders including rickets as summarized in Fig