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These phospholipid structures help keep the active ingredient safe while it is being processed and broken down, and they also make the substance more compatible with biological membranes

Adequate gastric acid is required for the activation of pepsin (protein digestion), normal gastric sterilisation of food (reducing the bacterial load entering the small intestine), and acid-dependent activation of pancreatic enzyme secretion

Furthermore, the acute metabolic response to 5FU treatment is profound and facilitates tolerance

Radiother Oncol 209:110993

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