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(170), transplanting the fecal microbiota of MDD patients into sterile rats led to an increase in fecal SCFA levels when compared to controls and sodium butyrate improved depressed behavior in rats

zero published human clinical trials as of this writing a 2021 peer-reviewed review states plainly that no NNMT-targeted clinical trials have been reported

And over time, many of the Navy Phase II.5 practices changed substantially in response to testing (the Office of Naval Research [ONR], for example, discontinued Phase II.5, while the Naval Sea Systems Command [NAVSEA] and the Naval Air Systems Command [NAVAIR] increased it but used different funding approaches)