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Consistently, Ddit4 Hep mice showed substantial resistance to the AMSCs-induced PGC-1 activation against APAP overdose, as Nrf1 and Tfam mRNA were not upregulated (Fig

Such directional consistency suggests a potential benefit that cannot be ruled out but likely requires better-designed, adequately powered randomized trials with standardized exposure and clinical endpoints

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Insomnia often begins as a temporary disruption but can evolve into a self-perpetuating, chronic condition with cortical overactivation, limbic dysregulation, and hypothalamic-pituitary-adrenal (HPA) axis hypersensitivity

doi:10.1007/BF02977603