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IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 Da
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Neuroscience and Behavioral Physiology, 22 (4), 275-279
Complementing this, work in isolated cell systems (consistent with the framework of Sun et al., 2010) reported that Hexarelin and ghrelin act on cardiomyocytes through GHS-R1a and protein-kinase signaling, with survival pathways such as PI3K/Akt and ERK1/2 implicated in protection from ischemia-reperfusion injury
(179) demonstrated that in rat models of NASH, HUC-MSCs exosomes enhanced the Nrf2 (Nuclear factor erythroid 2-related factor 2), a protective factor against oxidative stress and 1 [NAD (P) H quinone dehydrogenase 1], a part of cellular adaptive response to stress, which seems to play a significant part in treating NASH (180)
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