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Spermidine increased levels of LC3-II, TFEP and p62, which are important components of autophagy (Reference Omar, Omar and Shoela81)

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These reactive astrocytes exhibit altered behaviors that can both support and disrupt neuronal function, creating a complex environment that accelerates neurodegeneration

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This change in the rigidity disconnects the catalytic region from the GTP-binding sites, resulting in reduced motion of the Rossmann fold that fails to block the catalytic cleft as it observed in the closed type GDH conformation