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In fact, over the past couple of decades, aberrant intracellular ROS levels and the cell's inability to clear the oxidants have been implicated in various diseases, including cancer, neurodegenerative disease, cardiovascular disease, diabetes, and gastrointestinal disease (Box 2)

Neuroscience 303:558568 Fassett RG, Coombes JS (2011) Astaxanthin: a potential therapeutic agent in cardiovascular disease

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But here's the detail you should know: not having enough glutathione contributes to oxidative stress, which plays a major role in the mechanisms of complex disorders

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