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Anti-inflammatory effects complement the regenerative mechanisms, with TB-500 reducing inflammatory cytokine expression and limiting excessive inflammation that can impair healing

N -(carboxymethyl)arginine is one of the dominant advanced glycation end products in glycated collagens and mouse tissues

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EMBO J 18:13211334

Importantly, while traditional scaffolds primarily function as physical supports with limited versatility, and conventional treatments largely depend on such scaffolds, biomimetic microfiber scaffolds can load drugs, growth factors, or stem cells to achieve multifunctional regulation, such as antibacterial activity and angiogenesis promotion [198]