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When oxidative stress occurs, it damages neurons, disrupts signaling, and contributes to the progression of neurodegenerative disorders such as: Alzheimers disease Parkinsons disease Multiple sclerosis (MS) Amyotrophic lateral sclerosis (ALS) Over time, excessive oxidative damage impairs mitochondrial function the energy center of brain cells and accelerates neuronal decline
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128 Likewise, in macrophages, lactylation of K33 on NEDD4, a crucial E3 ubiquitin ligase, reduces the ubiquitination of Caspase-11 by diminishing their binding affinity, leading to Caspase-11-dependent non-canonical pyroptosis
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