38,39,40 This hypothesis was supported by altered total GSH concentration, GSH/GSSG ratio, and RT-qPCR validation of gene expression patterns in Con and Lig neutrophils (Fig S3af)
Among the monoclonal antibodies, rituximab (specific to the calcium-channel protein CD20 on the surface of B cells and mature plasma cells) increases ROS and induces apoptosis via the inhibition of Bcl-2 and p38MAPK signaling and is used in the treatment of B cell lymphomas 91
Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation
In order to maintain low levels of reactive oxygen species (ROS), ascorbate peroxidase (APX) and GPX convert hydrogen peroxide to water in the ascorbate (AsA)-glutathione (GSH) cycle and oxidized glutathione (GSSG)-GSH cycle, respectively [8, 9]
It can activate the division and migration of epidermal cells, promote the repair and regeneration of damaged tissues, and accelerate wound healing