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In this blend they are already combined, and the pairing has a mechanistic rationale: NAD+ supplies the coenzyme, while 5-Amino-1MQ blocks the NNMT enzyme that would otherwise drain NAD+ precursors [4]

This is marketing framing, not evidence no clinical trial or peer-reviewed study of any such combination exists in humans

Mnnikes et al., 2 and/or CRF 1 in the upper and CRF 1 in the lower gastrointestinal tract, prevented the delayed gastric emptying and the stimulation of colonic motility and defecation induced by various stressors in rodents (Tach and Bonaz, 2007)

doi: 10.1210/edrv.18.6.0321 40 IvarsenPChenJWTietzeIChristiansenJSFlyvbjergAFrystykJ