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The activity of these enzymes is enhanced by a variety of chemicals, including caffeine[40, 41] and anticonvulsant drugs[42], and it is well known that co-ingestion of these drugs with APAP can greatly enhance the toxicity of APAP

In case of an associated buccal gingival recession, coronally advanced entire papilla preservation (CA-EPP) technique has been proposed in the treatment of intrabony defects and adding connective tissue graft under the buccal flap may promote the gingival profile and stability [89]

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Discussion Melanogenesis is a complex process regulated by oxidative and glycation pathways, both of which are activated by environmental stressors such as UV radiation 8,19