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Imbalance in the synthesis and breakdown of lipids in cells, such as triglycerides (TGs), phospholipids, glycolipids, and cholesterol esters, leads to an excessive content of FAs in the liver, resulting in the deposition of lipids in the form of TGs within liver cells, which promotes the occurrence of MASLD (81)

This integrative shift (Figure 6) is being propelled by rapid advances in artificial intelligence (AI) and machine learning (ML), which have enabled the simultaneous analysis of large, heterogeneous datasets