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In the 1980s, a pilot preclinical study on two rat and monkey PD models 16 and two independent clinical cases 17,18 showed that intracerebroventricular (i.c.v.) administration of dopamine improved motor symptoms, but also resulted in tachyphylaxia, possibly owing to dopamine oxidation despite the use of a preservative solution (sodium metabisulfite), precluding the therapeutic development of this concept

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This isnt practical for individuals who suffer from chronic B12 deficiency or frequently deplete the entirety of their B12 stores

Sciatica symptoms can vary widely depending on where and how the nerve is affected

Numbness or tingling in the hands and feet could be a neurological symptom, emphasizing the importance of addressing B12 levels for nerve health