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Empagliflozin enhances neuroplasticity in rotenone-induced parkinsonism: role of BDNF, CREB and Npas4

10.1 Stage 1 Genetic and Epigenetic Vulnerability Stage 1 establishes the baseline sensitivity of a developing brain to environmental or physiological stressors

115 Mammalian xanthine oxidoreductase (XOR), one enzyme in purine catabolism, can exist in both dehydrogenase (XDH) form, which prefers NAD + as the electron acceptor, and XO form, which transfers the electrons directly to O 2 , leading to the formation of O 2 and H 2 O 2

Oxidation is triggered by exposure to light, air, and certain metals