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Diodati JG, Dakak N, Gilligan DM, Quyyumi AA

In-Vitro Pharmacology and Selectivity Biochemical profiling places 5-Amino-1MQ potency for research NNMT in the low-micromolar IC range under standardized assay conditions, with cell-based EC values in the low micromolar range for lowering 1-MNA and suppressing lipogenesis

An increased serotonin synthesis in rat substantia nigras (compacta and reticulate) structure (11, 16, 19, 22-25) parallels the antidepressant effect during the Porsolt's test (17)

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