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The body is unable to remove them efficiently, so they accumulate as biological waste that disrupts tissue homeostasis and accelerates degenerative changes

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Since this SSE is associated with a loss of sensitivity and accuracy, the above-mentioned sample preparation methods describe compromises between the minimization of these matrix effects by removing matrix components during sample clean-up, and the ability to detect a broad spectrum of analytes with reasonable sample preparation efforts and adequate sensitivity

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6 and Supplementary Fig