The oncoprotein c-Myc regulates nucleotide metabolism (Mannava et al., 2008)
R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation
Regina A, Koman A, Piciotti M, El Hafny B, Center MS, Bergmann R, Couraud PO, Roux F
Following exposure to an 8.0 mM glutathione and 100 U/L amidase mixture solution for 14 d, the MSN-ss-SA framework was almost entirely eroded, and no intact spherical nanoparticles were observed
The schematic in Figure 2C captures the sequential progression of hallmark AD features, such as amyloid plaques, tau tangles, neuronal loss, gliosis, synaptic degeneration, and cognitive decline