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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

Vegetarians or vegans may need vitamin B-12 injections or supplements

This effect has been noted in rat studies [4]

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Compressing the formula into one capsule would mean cutting doses, which is precisely what BioRestore is designed to avoid