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Regarding the role of 5-HT system in offspring of obese women, it has been shown that a high-fat diet reduces 5-HT synthesis in offspring, associated with reduced serotonergic axonal density and embryonic neuronal survival in human brain regions critical for behavioral regulation, and contributes to an increased risk of neurodevelopmental pathologies such as ADHD, ASD, anxiety, and depression

Everything else is protocol refinement, not risk management

Via bidirectional crosstalk, PVAT is related to the vascular wall

31 , 10781090.e5 (2020)

It works well on its own, but using it with other compatible products will increase its efficacy