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People with the following should discuss risks carefully with a medical professional: Liver disease Kidney disease Pernicious anemia Known allergies to any ingredient in the formulation Pregnancy or breastfeeding (safety not well-studied avoid unless prescribed) Because ingredients differ between providers, always verify the formulation and follow prescribed dosing to minimize risk

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When patients with hepatitis C were given standard therapy or standard therapy with a B12 injection of 5,000mcg, every 4 weeks for 48 weeks, those with the additional B12 responded better to treatment (18)