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Eosinophils themselves release a variety of mediators, including major basic protein (MBP), which enhances mast cell activation and further promotes histamine and leukotriene release

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In addition, based on clinical research, it is important to identify the syndromes and conditions that can benefit from the KD-based therapies, contraindications for use, KD variants with good effectiveness and tolerability, and factors and biomarkers that can predict KD-related outcomes, which may collectively guide the clinical utilization of the KD in different diseases

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PD Parkinson's disease growth factors are universally large proteins that are both metabolically labile and too large to pass the blood- brain barrier (BBB)

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