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Vitamin B12 injections work by directly replenishing depleted cobalamin stores, supporting two crucial enzymatic processes: methionine synthesis for nerve myelination and methylmalonyl-CoA conversion for energy production

Medical News Today reports that vitamin B12 injections are only available by prescription and must be administered by a licensed medical professional

The ideal B12 supplement contains a mix of methylcobalamin, hydroxocobalamin and adenosylcobalamin (11)

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Monitoring-guided supplementation is the usual approach, typically beginning with oral supplementation if blood tests indicate suboptimal levels, and escalating to IM injection if oral treatment is insufficient or poorly tolerated