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Elevated Ox-LDL is linked to coronary artery disease, heart attack, metabolic syndrome, and oxidative stress

The study was conducted in accordance with the International Conference on Harmonization Guidelines for Good Clinical Practice and the Declaration of Helsinki

Further consistent with this mechanism, Gem pretreatment did not suppress ferroptosis induced by the direct GPX4 inhibitor ML162, whose ability to induce ferroptosis is independent of intracellular GSH pools (Yang et al, 2014) (Fig 4F)

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Metabolic burden in hepatocytes activates multiple cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis, which can further amplify the inflammatory and fibrogenic response ( Figure 1B )