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Novel unimolecular tetra-agonist peptides targeting GLP-1, GIP, amylin, and calcitonin receptors with enhanced metabolic benefits in animal models of obesity

Surez-lvarez, B., Liapis, H., & Anders, H.-J

Research scenario Better conceptual fit Reason Testing GLP-1 plus satiety-pathway extension CagriSema Combines semaglutide with amylin analog activity Testing maximum receptor breadth Retatrutide Activates GIP, GLP-1, and glucagon receptors Studying diabetes plus obesity together Both Both have programs relevant to T2D and weight Comparing incremental vs radical next-gen strategy Both CagriSema extends GLP-1

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Shapson-Coe, A