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L-methionine, 100mg therapy resulted in a significant increase of hepatic glutathione levels both in patients with alcoholic and in those with non-alcoholic liver diseases as compared with placebo-treated patients

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BACH1 itself is a direct transcriptional target of HIF1A, which binds its promoter under hypoxic conditions to induce expression 174 , highlighting a multilayered transcriptional network linking hypoxia, GSH metabolism, and cuproptotic vulnerability