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It depends on your lifestyle, diet, stress levels, and symptoms

To put that in perspective, the best semaglutide clinical trials showed approximately 15-17% weight reduction, and tirzepatide results peaked around 20-22%

10.1210/en.2004-0037 Endocrinology 19 DArgenioA.MazziC.PecchioliL.Di LorenzoG.SiracusanoA.TroisiA

Compared with placebo, pioglitazone significantly reduced the histologic feature scores, and a greater proportion of subjects in the pioglitazone group achieved resolution of MASH

These observations suggest CD8+ T cells are initially monospecific and reside in the pancreas as a default state, only becoming multi-specific and infiltrating the islet as pathogenesis advances